American League East:
- Baltimore Orioles
- RHP Gray Fenter
- INF/OF – Juan Montes
- Boston Red Sox
- LHP Darwinzon Hernandez
- OF – Tyler Esplin
- New York Yankees
- RHP Deivi Garcia
- SS – Oswald Peraza
- Tampa Bay Rays
- RHP Mikey York
- 1B – Devin Davis (Davis, a 2015 – 25th rounder out of Valencia HS (CA) was the first runner-up for the Rays OAS list first baseman honor. That went to Nathaniel Lowe. However, Davis, and his plus-plus bat speed, saw a drastic rise in extra bases last season).
- Toronto Blue Jays
- RHP Maximo Castillo
- CF – Steward Berroa
American League Central:
- Chicago White Sox
- RHP Yosmer Solorzano
- CI – Justin Yurchak
- Cleveland Indians
- RHP Gregori Vasquez
- 3B – Nolan Jones
- Detroit Tigers
- RHP Tom de Blok
- INF – Anthony Pereira
- Kansas City Royals
- RHP Gerson Garabito
- OF/INF – Travis Jones
- Minnesota Twins
- LHP Tyler Watson
- SS – Wander Javier
American League West:
- Houston Astros
- RHP Leovanny Rodriguez
- CF Myles Straw
- Los Angeles Angels
- LHP Jose Suarez
- 1B – David MacKinnon
- Oakland Athletics
- RHP Brian Howard
- 1B – Iraj Serrano
- Seattle Mariners
- LHP Danny Garcia
- SS – Alexander Campos
- Texas Rangers
- RHP Edgar Arredondo
- CI/CO – Yanio Perez